As it has previously mentioned in other threads, Desmond's Medicine containers all include the numbers on their individual labels CR 4 - 8151623 - 42. If you notice when Desmond then goes to the gun locker the combination shows it starting on 23 and then he turns to 42 to open. I am rewatching for other instances.
The number 42 also showed up in the mural, next to a picture of a fish, over a house that said "Sick". 108 was inside a picture of the sun. Definitely looked like a child's drawing. Maybe Alex?
I believe that 16 was also on the painting, and 108 is the sum of the numbers. I'm pretty sure that the numbers, separated by spaces, were typed at the green computer prompt...
Wow, you people are smart! I never picked up that 108 was the sum of the numbers. And that painting seemed to say I'M SICK somewhere. Could be Alex, but the paint looked like it had been used recently. As we saw other buckets and stuff, they were caked in dust and dirt. The paint wasnt. I wonder why...?