This is not my idea, I borrowed it from Sam G. But I liked it so much, I thought it might be fun to do it here as well. It is not necessary to be serious
I hope we'll find many things to add. If you have better definitions, please add yours!
4 8 15 16 23 42: If i ever get home im gonna write these on a billboard then burn it! ! ! (by carfreak2128)
?: what this whole snowglobe of an Island is; another name for the Pearl Station. (by STH)
Alvar Hanso: lunatic who financed all this Dharma mess.(by STH)
Apollo bar: tasty candy in the hatch that Kate loves!(by STH)
Armory: good for storing guns; better for stashing captured Others/Hostiles.(by STH)
Back-pack : comes in handy when you want to carry a stuffed bunny, some medicine and the Third Policeman around
Beard's length - the measure of his despair
Blender: makes a great smoothie. (by STH)
Bottle of Booze: takes the sting out of being trapped in a snowglobe.(by STH)
Boxman - the guy who's not "him", but saves his life nonetheless
Brutha - a name for every fellow sufferer
Bunker - his residency for the last 3 years
Charlie: some guy Eko had with him.(by STH)
Claire: pretty Aussie girl with a luvleh baby boy. (by STH)
Coffee: elixir of life. (by STH)
Coffeeklatch with Desmondites: would tie with
Rejecting (Charles) Widmore's bribe for best idea he ever had--if he'd just HAVE it!! (by STH)
Coffeeshop: good place to go if you need a sailboat; cuz you've gotta have a good cuppa sometimes!(by STH)
Computer printout: informed him that he'd crashed Flight 815 (apparently).(by STH)
Desmondites - followers of the D (according to Sam G's Dictionary of Lost)
Dharma:
(by STH)
Dharma booze: nothing to brag about, but Desmond swears it'll do in a pinch!(by STH)
Dharma ranch dressing: Hurley swears it adds "oomph" to mango slices.(by STH)
Dharma steak dinner: better than MREs, that's for sure! (by STH)
Dharma toasted oat cereal: Fenry swears it tastes better with milk!(by STH)
Dharma trail mix bar: tasteless food that not even Hurley would eat.(by STH)
Eko: a priest he locked out of the hatch. Oops!(by STH)
Electromagnetic anomaly - when Des and Penny get separated
Elizabeth (the boat) - boat of friendship and catastrophe
Elizabeth (the lass): nice woman who bought him coffee and gave him her boat.(by STH)
EMT: something that makes FAR too much light and noise! (by STH)
Every Single Day: how often he wonders if this is all just a mind game.(by STH)
Every luvleh word - he knows by heart from Penny's letter
Execute: button to push every 108 minutes; something that should be done to (Charles) Widmore and Dharma. (by STH)
Failsafe: what will end the need to press the button--well, we'll soon know about THAT! (by STH); the key which enlightens his already magnetic personality
Get out much: something he didn't do for three years; now free to do a lot!(by STH)
Green Dharma Cup - even tapwater tastes like coffee from it
Hair: Something that Desmond has a lot of (see also, Luvleh). (by jbdean)
Hatch pipes: good for doing chin-ups.(by STH)
Hazmat suit: dirty, rotten costume Kelvin used to keep him hatchbound.(by STH)
Honor - bloody hard to get it back!
Hostiles - the ones best to ignore
I Am Here: the Swan Station, on the map.(by STH)
Incident: the reason Desmond--and all the Swan's personnel--got their jobs.(by STH)
Jack: a great guy, if he weren't such an Eeyore all the time. (by STH)
Jumpsuit - latest fashion on Craphole-island; proof positive that Dharma has no project related to fashion.(by STH)
Jungle: there sure is a lot of it on this Island!(by STH)
Kate: The first babe i've seen in three years ((by carfreak2128)); fugitive woman who can fit self in hatch vents; loves Apollo candy bars.(by STH)
Kelvin - thief of lives, bully of the hatch; see Dharma (by STH)
Key: something you have to turn to save the world. (by STH)
Lava Lamp: after awhile in the hatch, watching it got to be exciting! (by STH)
Lift it up: expression meaning "cheer up," or "don't be such an Eeyore"! (by STH)
Lockdown: when you are even more locked in the hatch than usual.(by STH)
Locke: My crazy button pushing friend (till the finale) ((by carfreak2128)); faith-challenged dude who used to make boxes; aka "Boxman."(by STH)
Luvleh: Claire's baby and Desmond.(by jbdean)
Magnetism: something both he and the hatch have a lot of!(by STH)
Mama Cass Elliot: makes her own kind of music.(by STH)
Map on Door: tells you more about Dharma and the Island than you really want to know--but NEED to know!(by STH)
(Dr.) Marvin Candle: orientation film narrator; mouthpiece for Dharma/Hanso.(by STH)
Mural: no Rembrandt, but it'll do.(by STH)
Nice old lady: Kelvin's term for Queen Elizabeth II, as in "nice old lady's army."(by STH)
Orientation: A briefing to fill you in on what's going on (or so you think). (by jbdean)
Orientation film - the only show on tv for the last 3 years!
Our Mutual Friend: Desmonds life and joy ((by carfreak2128)); last book I'll read before I die. (by STH)
(Our) Mutual Friend: A book by Charles Dickens and what it seems Jack, Locke and Libby are to Desmond. (by jbdean)
Outside: a luvleh place to be! (by STH)
Pantry: place to keep Dharma food supplies; makes a lousy cell to lock Kate in.(by STH)
Pearl Station Oriention Film - the prequel of the "only show on tv for the last 3 years" that he never came to see
Penny - love forever, true;
!!
Penny's letter: the finest piece of literature he's ever read!(by STH)
Periscope: the better to see you with.(by STH)
Ping-Pong table: not much use when there's only one of you in the hatch; after 3 years, Desmond can beat all challengers at the game!
(by STH)
Phonograph: what people played music on before they invented CDs.(by STH)
Pocket watch: What Desmond was given when he was released from prison and what the narrator of The Third Policeman was looking for (though he never really had one to begin with). (by jbdean)
Popcorn: what Locke offered Desmond if he'd come to the Pearl Station and watch that station's orientation film!(by STH)
Race around the world: worst idea he ever had!(by STH)
Record collection: some Dharma dude had a real Oldies obsession!(by STH)
Rejecting (Charles) Widmore's bribe: best idea he ever had! (by STH)
Rifle: weapon of choice.(by STH)
Running - hope he'll do that for fun from now on
Quarantine - was I, or was I not in one?
Sayid: Iraqi chap who wants to sail up the coast to find Hostiles. (by STH)
Scotland: home.(by STH)
Sea: Something he sailed for 2-1/2 weeks, and got NOWHERE; a place you do NOT want to be during a storm! (by STH)
Shake - a drink that Desmond's fixes and what happens to the Swan Station when the button's not pushed. (by jbdean)
Shaving - 'cos he's never gonna let go, brotha!
Sickness: a deadly disease that Kelvin
said was on the Island.(by STH)
Smoothie: drink of choice (when there's no coffee around).(by STH)
Snowglobe: something all of us on the Island are inside. (by STH); something he won't buy for Christmas
Snowman: asks the other snowman if he smells carrots.(by STH)
Sofa: in the hatch, a more comfy place to sit than the computer chair.(by STH)
Solo race around the world: was rudely interrupted for Desmond!(by STH)
Southway Garrison - He thought he was free at last when he left it...
Speaker: crackles a lot when there's about to be a lockdown.(by STH)
Stadium: good place to reunite with Penny and meet great guys like Jack; running through stands good preparation for boat race.(by STH)
Stuffed bunny: probably IS his fave animal!(by STH)
Swan - probably not his fav animal
The Boat Race: the ticket to a luvleh future and restored honor. At least, that's what it was SUPPOSED to be! (by STH)
The Mamas and the Papas: The only real family Desmond had in the Swan after Kelvin died (by jbdean)
The next life: a farewell meaning, "till we meet again." (by STH)
The Third Policeman: the Hostiles got the first two!
(by STH); the book that was
almost the last one he read
The Turn of the Screw: a book in the hatch library; what one does when fixing a computer that's been shot at.(by STH)
United States: nice place to visit, but it's no Scotland!(by STH)
Vaccine: prevents one from getting sick--that is, if there IS a sickness!(by STH)
Weights: good for building muscle and holding lowered hatch doors open.(by STH)
(Charles) Widmore: see
Dharma(by STH); the dragon to slay; a British breed of donkey (by jbdean)
Widmore Industries: corporation that's too big for its britches; see
Charles Widmore.(by STH)
You: Desmond's nickname for Jack (by jbdean)
You rock! 
Keep up the good work! 
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